ANN ARBOR: University of Michigan launches new clinic for 'high-risk' prostate cancer

Dr. Ganesh Palapattu, director of the new high-risk prostate cancer clinic at the U-M Comprehensive Cancer Center.

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ANN ARBOR ? While every year about 30,000 men die of prostate cancer in the United States, the most common cause of death in men with prostate cancer is heart disease. That?s because not all prostate cancers are the same. Some are slow-growing while others are very aggressive.

?The University of Michigan Comprehensive Cancer Center has started a new clinic focused on men with the fast-growing type of cancer. This kind of high risk disease is thought to possess a high likelihood of causing harm.

?These men will likely need more than one treatment because we know these types of cancers tend to recur. Patients with aggressive cancer need extra attention and a high level of care, including genetic information and a consensus opinion from different experts,? says Dr. Ganesh Palapattu, director of urologic oncology and director of the new high-risk prostate cancer clinic at the U-M Comprehensive Cancer Center.

?The clinic brings together experts in urology, medical oncology, radiation oncology and pathology. All of these specialists review cases together, discussing each patient?s unique factors and agreeing on the best treatment plan.

Patients also receive free cancer genome sequencing along with several recently introduced predictive genetic tests. Clinical trials are offered when appropriate.

?For patient Jeffrey Roberge, 49, the idea of all the experts working to a consensus opinion helped make the process easier.

Roberge was diagnosed with prostate cancer in August 2012. His cancer had not spread but was at high risk to do so. Roberge underwent surgery in January and has had regular PSA tests since ? all of which have come back negative for cancer.

?It?s daunting when you?re not a professional and you don?t understand all the options. When you have several doctors giving you their shared opinion, it makes it easier to help you make your own decision,? Roberge says. ?I didn?t feel like I was floating around on my own trying to figure it out. We were all moving through the process together. That?s comforting.?

?The high-risk prostate cancer clinic also offers survivorship services, including a team of social workers and other health care providers who help patients and their families deal with the challenges that go along with a cancer diagnosis.

As evidence grows that no two cancers are the same, doctors are more and more focusing on precision medicine, in which the particular genes, proteins or other markers in an individual?s tumor tell doctors what kind of drug might be more effective ? and what might be less effective. It allows patients to avoid drugs that are not likely to work for them. Continued...

?While prostate tumors may look the same from one patient to the next under a microscope, they may behave quite differently. This kind of behavior is driven largely by the genetics, the DNA sequencing of the cancer. Information about this DNA sequence or genetic sequence can be helpful in the future as we tailor therapy for a patient if the cancer recurs or comes back again after initial therapy,? Palapattu says.

?We treat patients, not diseases. Our goal is to offer individualized treatment plans focused on each individual,? he adds.

What is high-risk prostate cancer?

Doctors start with the results of blood tests and biopsies to guide the classification of high-risk prostate cancer. The key is that these are tumors likely to return or spread and cause poor outcomes.

Some of the markers that come into play include:

? Gleason score (8 or more)

? PSA score (20 or more)

? Advanced stage (T3 or higher)

? Relapse after prior surgery or radiation therapy

?To make an appointment with the high-risk prostate cancer clinic, call the U-M Cancer AnswerLine at 800-865-1125. Continued...

ANN ARBOR ? While every year about 30,000 men die of prostate cancer in the United States, the most common cause of death in men with prostate cancer is heart disease. That?s because not all prostate cancers are the same. Some are slow-growing while others are very aggressive.

?The University of Michigan Comprehensive Cancer Center has started a new clinic focused on men with the fast-growing type of cancer. This kind of high risk disease is thought to possess a high likelihood of causing harm.

?These men will likely need more than one treatment because we know these types of cancers tend to recur. Patients with aggressive cancer need extra attention and a high level of care, including genetic information and a consensus opinion from different experts,? says Dr. Ganesh Palapattu, director of urologic oncology and director of the new high-risk prostate cancer clinic at the U-M Comprehensive Cancer Center.

?The clinic brings together experts in urology, medical oncology, radiation oncology and pathology. All of these specialists review cases together, discussing each patient?s unique factors and agreeing on the best treatment plan.

Patients also receive free cancer genome sequencing along with several recently introduced predictive genetic tests. Clinical trials are offered when appropriate.

?For patient Jeffrey Roberge, 49, the idea of all the experts working to a consensus opinion helped make the process easier.

Roberge was diagnosed with prostate cancer in August 2012. His cancer had not spread but was at high risk to do so. Roberge underwent surgery in January and has had regular PSA tests since ? all of which have come back negative for cancer.

?It?s daunting when you?re not a professional and you don?t understand all the options. When you have several doctors giving you their shared opinion, it makes it easier to help you make your own decision,? Roberge says. ?I didn?t feel like I was floating around on my own trying to figure it out. We were all moving through the process together. That?s comforting.?

?The high-risk prostate cancer clinic also offers survivorship services, including a team of social workers and other health care providers who help patients and their families deal with the challenges that go along with a cancer diagnosis.

As evidence grows that no two cancers are the same, doctors are more and more focusing on precision medicine, in which the particular genes, proteins or other markers in an individual?s tumor tell doctors what kind of drug might be more effective ? and what might be less effective. It allows patients to avoid drugs that are not likely to work for them.

?While prostate tumors may look the same from one patient to the next under a microscope, they may behave quite differently. This kind of behavior is driven largely by the genetics, the DNA sequencing of the cancer. Information about this DNA sequence or genetic sequence can be helpful in the future as we tailor therapy for a patient if the cancer recurs or comes back again after initial therapy,? Palapattu says.

?We treat patients, not diseases. Our goal is to offer individualized treatment plans focused on each individual,? he adds.

What is high-risk prostate cancer?

Doctors start with the results of blood tests and biopsies to guide the classification of high-risk prostate cancer. The key is that these are tumors likely to return or spread and cause poor outcomes.

Some of the markers that come into play include:

? Gleason score (8 or more)

? PSA score (20 or more)

? Advanced stage (T3 or higher)

? Relapse after prior surgery or radiation therapy

?To make an appointment with the high-risk prostate cancer clinic, call the U-M Cancer AnswerLine at 800-865-1125.

FYI

According to the American Cancer Society, 238,590 Americans will be diagnosed with prostate cancer this year and 29,720 will die from the disease.

Source: http://www.heritage.com/articles/2013/08/03/ann_arbor_journal/news/doc51facfbff2b08515198955.txt

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Zimbabwe president's party withdraws victory claim

HARARE, Zimbabwe -- The main challenger to Zimbabwe's longtime president, Robert Mugabe, said Thursday the election is "null and void" due to alleged violations in the voting process, but Mugabe has denied vote rigging.

Prime Minister Morgan Tsvangirai said Wednesday's election was heavily manipulated and did not meet regional or African election standards. A poll monitoring group that is not affiliated with the state also said the poll was compromised by a campaign to stop voters from casting ballots.

Mugabe has denied allegations of vote-rigging as a smear campaign by opponents. Final results are expected by Monday.

The elections posed one of the biggest challenges to Mugabe's 33-year grip on power on this former British colony in southeast Africa.

"The shoddy manner in which it has been conducted and the consequent illegitimacy of the result will plunge this country into a serious crisis," Tsvangirai warned.

The head of African Union observer mission, former Nigerian President Olusegun Obasanjo, said late Wednesday that reports of irregularities "will be investigated but have not yet been substantiated."

Mugabe's party said Thursday it has withdrawn an unauthorized message on its Twitter feed claiming a resounding victory. The ZANU-PF party said it is awaiting the release of results by the state election commission, the only body allowed under the law to announce the outcome of massive voting on Wednesday.

Solomon Zwana, head of the Zimbabwe Election Support Network, said Thursday it has found a "wide range of problems" in the election and that the poll was compromised by a campaign to stop voters from casting ballots. The monitoring group says as many as 1 million out of more than 6 million eligible voters were not on voters' lists.

Zimbabweans voted in large numbers Wednesday in an election that was peaceful compared to disputed and violent polls in 2008. Thousands of voters lined up in Harare's populous Mbare township but by Wednesday evening all the voters had been accommodated, said polling officials. "It's a tremendous turnout," said Magodelyo Yeukai, Mbare presiding officer.

Polling officials and party agents brought blankets to polling stations so that they could sleep next to the polling boxes to make sure they were not tampered with.

Mugabe, 89, has said he would step down if he loses.

Zimbabwe's shaky government was effectively dissolved on Wednesday. Mugabe and Tsvangirai have each predicted outright victory that would avoid the formation of another coalition.

Half the population of 12.9 million was eligible to vote. The state election body has said administrative, logistical and funding problems hindered voting arrangements, but said the problems have been fixed at the more than 9,000 polling stations nationwide.

Previous elections in 2002 and 2008 were marred by allegations of vote-rigging and political violence. Rights groups say there has been little overt violence this time but noted deep concerns over voters' lists, the role of Mugabe's loyalist police and military in the voting process and bias in the dominant state media and the sole national broadcaster controlled by Mugabe loyalists.

The International Crisis Group, a research organization, said it fears a return to a protracted political crisis and possibly extensive violence if the Zimbabwe poll is inconclusive and disputed.

Source: http://www.miamiherald.com/2013/08/01/3535635/zimbabwe-presidents-party-withdraws.html

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Mark Romanek, 'Picasso Baby' Director, Says New Jay Z Film Documents A 'Tsunami Of Joyfulness'

If the art world and the hip-hop world have one thing in common, it's a hearty appetite for controversy. (And before members of both camps start flaming me, yes, I realize they have more than just that in common.) So it was probably inevitable that Jay Z's decision to stage a "performance piece" at the Pace Gallery over the course of six hours would stir passions. To some in the art world, ever suspicious of celebrity incursions, it was a debasement of the form. To some in the hip-hop world, ever suspicious of crossover betrayals, it was a flagrant display of elitism.

But what was Jay Z himself trying to achieve? According to Mark Romanek, who conceptualized the event and directed the resulting half-hour documentary (set to air on HBO this Friday at 11 pm), the inspiration was simple. Romanek had seen the 2012 film "Marina Abramovic: The Artist Is Present," which documented the Serbian-born artist's marathon series of one-on-one interactions with visitors at the Museum of Modern Art in New York, and become fascinated by the intimacy she achieved. "What I pitched to Jay was: 'You regularly perform to 60 or 80,000 people at a time. What if you performed for one person at a time? What if it was like Marina's piece?"" Romanek says.

That helps explain why Romanek insists on calling the "Picasso Baby" session a piece of performance art, rather than a music video. And it helps explain why Jay Z rapped the lyrics live instead of lip syncing -- despite what you may have read in Gawker or The New Yorker. "They're both dead wrong," Romanek says. "At no point during the day did he lip sync. He did live vocals for six hours. The finished piece was always intended to be live vocals. I mean, that was the whole point of it. Otherwise, it would turn into a music video."

Romanek has directed some of the most memorable music videos of the past 20 years, including Johnny Cash's "Hurt," Fiona Apple's "Criminal" and Jay Z's "99 Problems," but he's mostly focused on features these days. His 2002 film "One Hour Photo," with Robin Williams in the lead, grossed $31 million domestically, and in 2010 he followed it up with "Never Let Me Go," starring Carey Mulligan and Andrew Garfield. So when Jay Z called and proposed a collaboration, Romanek had to ask himself if he wanted to do another music video. "And the answer was no," he says. "But do I want to work with Jay Z on this amazing album? The answer was absolutely, so how do we invent a new thing that we would both be excited by?"

I chanced into an invitation to the "Picasso Baby" shoot (event? happening? I don't know what to call it anymore), and thought it was pretty cool. Earlier this week, I asked Romanek how it all went down. Here are some highlights from our conversation.

How did the idea for all this come about?

About three months ago, Jay invited me to his office to hear the album. I was really impressed. I thought it was his most mature album and I thought it was a real leap for him, and we both expressed a dissatisfaction with the way things are done and a desire to do something different. He name-checks a lot of artists, so it immediately put me to mind of the whole fine-art world, and since he's a performer I started thinking about a performance-art piece involving Jay's music. And every time we tried to think of something that was radically different from Marina [Abramovic]'s piece, it never seemed as good. So we said, what if we do something very much like that? But it was important to me that we weren't just ripping her off, that we had her blessing, so we reached out to her and she loved the idea and said she'd be happy to bless the event with her presence. The phrase "music video" got tossed around a little bit at the beginning, and both of us were like, "We don't want to do a music video. That's from another era. We need to do something that's more genuine, more spontaneous and more alive."

So you do reject the term "music video" for this project?

Yeah. I mean, I don't think that's what it is. I think it's a document of an art happening in the old-school sense of an art happening. We had no idea how it was going to go. It could have flopped. It could have been a dud. It wasn't. It was really fun and exciting. Jeanne Greenberg Rohaytn helped us assemble a guest list of people from the art world that we hoped would have a lot of variety. We set it up as much as we could as if it were an art event -- the invitations and the posters and the text on the wall. And then we sort of flipped the "on" switch and filmed what happened. I was not really controlling anything. All I was trying to do was control it as a filmmaker by monitoring the cameras and making suggestions about how to cover it.

So you had Jay on a platform, one notable person watching him, then a whole group of people around the perimeter of the room. How did you come up with that basic setup?

The initial thing, what I pitched to Jay was, you regularly perform to 60 or 80,000 people at a time. What if you performed for one person at a time? What if it was like Marina's piece? And it evolved from there in terms of how to build it, and he got very excited by that. I mean, halfway through me pitching it to him, he said, "Wait, wait, I got chills. That's exactly what we should be doing." In terms of notable people, obviously we wanted it to have an art-world slant, but it's a somewhat democratic range of people. There were bands that were invited that are just Jay Z's fans, there were people that are just New York people, they're actors and musicians and other New York people. We wanted it to be a mix.

Whose idea was it to invite the larger group to crowd around toward the end of the song?

The song is unique in that it's sort of broken into two parts. The first half of it is one kind of track, and then it doesn't just slightly change, it completely changes. So Jay and I did discuss, well, what are we going to do visually to highlight that big shift in the song? And I suggested, what if you invite people to break that barrier and just invite them in? So we tried it, and it did create a new energy for that second part of the track.

One of the defining features was the social-media sharing inside that room. My feelings about it went from, I can't believe they're letting me take pictures, to, Oh, of course, this is exactly what they want. But was it what you wanted, or did that just kind of occur?

Well, from the very beginning, part of the basic pitch was, we'll let people do social media, we'll let people Tweet about it, we'll let people take pictures. That was definitely part of the DNA of the thing, and part of what we thought would feel very of-the-moment about it. What we wanted to do was control it a little bit so that maybe it was going to be people waiting outside, you know, peeking in. And then, a la Abramovic, we put up all these signs saying NO PHOTOGRAPHY INSIDE THE GALLERY. And that became a joke after about three seconds. There are 250 people in the room and 249 of them had a camera out, so we had a choice to make at that point. We could either become sort of fascist about it and say, "Oh, put your cameras away," or just go with it. And instantly everyone said let's just go with it. And I think it turned out great. When you see the finished piece, I think you'll see that it didn't really spoil anything, because frankly the finished piece is more polished and more beautiful.

When I was there, he was rapping, and yet Gawker and Sasha Frere-Jones of The New Yorker have reported that he was lip syncing. Did he lip synch at all during the performance?

They're both dead wrong. It was never meant to be lip synced. At no point during the day did he lip sync. He did live vocals for six hours. The finished piece was always intended to be live vocals. I mean, that was the whole point of it. Otherwise, it would turn into a music video. He had a lavalier microphone on his chest that captured a beautiful vocal. It's completely obvious when you see the piece that it's not lip synced. Because every inflection and emotion that he performed on that day is different than anything like what's on the album. He's laughing. And one woman in her 60s showed up who was so elegant that he literally became speechless. He said, "You're making me lose my flow, but I'm gonna get it back in a minute." So we kept that in the video. He stopped singing at times and just talked to people, he kissed people. What you'll see is that it's like a tsunami of joyfulness. It's sort of the opposite of the tough-guy street-rapper clich?. Everyone is having such a good time and none of it is feigned. There's not a single fake moment in it. It's just a document of people having a really good time, Jay included.

I thought the live performance was key to that. To stand there and watch Jay lip sync would be one thing, but to be in a gallery space with him and listen to him rap with no in-room amplification -- everybody in there had to realize they were witnessing something special.

That was the whole point. For him to lip sync would be completely foundationally short-circuiting the whole point. I think that those people, Jones and Gawker, seem to have an axe to grind about the whole thing. You know, people are critiquing it based on a teaser and some other press. It's come to the point where people make reviews of trailers rather than waiting for the actual piece.

While we're on the topic of that New Yorker piece, Sasha Frere-Jones also writes that, in the wake of the Trayvon Martin verdict, Jay's album feels irrelevant, especially compared with Kanye West's angrier "Yeezus." What's your take on where Jay-Z is as an artist right now and how that relates to the moment we're experiencing?

You know, it's not my job to have a take on it publicly. I think it's his best album. I think it's extremely mature. It's not an album filled with catchy pop hits. It's a much more mature expression of where he's at right now. I listen to it constantly. I listen to the Kanye record, too. I think they're both very good records. They're obviously both very different. But my opinion is that it's Jay's best album. If Mr. Jones disagrees, that's his decision.

You and Jay collaborated on the "99 Problems" video nine years ago. How different was the collaboration this time around?

Well, it was the same in the sense that it was an excellent professional experience. He's not a micromanager. He likes to work with talented people and he'll be very firm about certain foundational aspects to it, but then after that he'll be very trusting and allow you to do what he's asked you to do on his behalf as a collaboration. But we're both nine years more mature. We're both parents now and we weren't before, and we both have different interests. And in a lot of ways I think, as different as our upbringings were, we seem to have affinities for the same ideas.

You've directed some of the coolest music videos ever. Do you really think the era of music videos is over?

Well, I haven't been thinking about music videos, I've been thinking about features. So when he said, "Would you like to do something?," that's when I said, "Oh, do I want to do a music video?" And the answer was no. But do I want to work with Jay Z on this amazing album? The answer was absolutely, so how do we invent a new thing that we would both be excited by? I guess in this day and age it just seems that, to come up with a concept and then artificially execute it and then have it be this finished, hermetically sealed thing is really irrelevant to what's going on in the world.

What's your favorite music video ever?

That's a tough one. I mean, the one that pops into my mind is one Spike Jonze made for the band Wax. The song is called "California," and it's that man running down the street in slow motion on fire. And it's all a single take. To me that's truly a piece of short film art that works perfectly as a music video. It's perfect and brilliant and human.

"Picasso Baby: A Performance Art Film" debuts on HBO on August 2 at 11 pm ET.

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Source: http://www.huffingtonpost.com/2013/08/01/mark-romanek-picasso-baby_n_3683437.html

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Soccer and Society: Cristiano Ronaldo juggles baseball at Dodger Stadium

In our latest installment of Soccer and Society, a periodic feature chronicling the intersection of the beautiful game and American life ?

While in Los Angeles with Real Madrid, Cristiano Ronaldo dropped by Dodger Stadium on Wednesday night to throw out the ceremonial first pitch. Better with his feet than with his hands: He had trouble finding the strike zone but juggled a baseball exquisitely with Yasiel Puig, the Dodgers? Cuban slugger. Watch:

Here he is taking a few cuts ?

And tossing the first pitch ?

Source: http://www.washingtonpost.com/blogs/soccer-insider/wp/2013/08/01/soccer-and-society-cristiano-ronaldo-juggles-baseball-at-dodger-stadium/

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WWE House Show Results 07.30.13 - Cape Town, South Africa

WWE House Show Results 07.30.13 - Cape Town, South Africa
Posted by Jeremy Thomas?on 07.30.2013

Orton gets attacked by a fan...

Credit: David Kruse & PWInsider

The WWE will be performing two shows in the Grand Arena, the first of which took place tonight. The venue holds only around 5000 people but they were having ticket deals to help fill out the venue and there were still plenty of empty seats, hope that doesn't hurt chances of bringing down WWE in the future. Justin Gabriel of course appeared in various TV and radio interviews throughout the week.

R-Truth beat Fandango after 7 minutes.

AJ beat Kaitlyn after 6 minutes.

RVD beat Wade Barrett after 8 minutes with the Five Star Frog Splash. Kind of a one sided match with RVD hitting all of his popular moves.

Justin Gabriel beat Titus O'Neil after 13 minutes with the 450 splash. Simple but enjoyable match. Quite a few moments where it looked like it was over for Gabriel which definitely heightened the tension for everyone in the venue.

Randy Orton beat Big E Langston after 9 minutes with an RKO. During Orton's celebration on the turnbuckle, a crazed fan jumped the railing and hit Orton on the back! Orton kicked the fan and gave him the middle finger as he was being dragged out the ring by security. The fan may have also attacked Big E at ringside. Orton looked peeved off at the security. The security at ringside beefed up big time after that.

Tons of Funk and a Funkadactyl beat Damien Sandow, Cody Rhodes & Brie Bella after 8 minutes.

Sheamus beat Jack Swagger, with Zeb Coulter, after 15 minutes. This was a solid match which ended with a sudden Brogue Kick which the fans loved.

World Heavyweight Championship Match: Alberto Del Rio beat Dolph Ziggler after 16 minutes with a sudden kick to the head. The fans choice was No DQ Match. Very nice match. They used a kendo stick and a table in the corner. After the pin, Ziggler got revenge on Del Rio by throwing him into a chair propped in the ropes and closed the show. My personal match of the night.

Overall it was a solid show. I would give it a 7/10 from a live perspective.

Must-read news from around the site:
* Six new clips released for Kick-Ass 2
* X-Men: Days of Future Past viral marketing features sentinels
* CW rumored to develop a Flash TV series
* Supernatural getting a Chicago-set spinoff
* Kat Dennings says Thor: The Dark World is heading into reshoots
* Update on villains returning for season two of Arrow
* The Top 5 Guitarists
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* The Top 8 DC Animated Films

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Source: http://www.411mania.com/wrestling/news/292503

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Video Confession: Shailene Woodley & Miles Teller of The Spectacular Now

by Grae Drake | Wednesday, Jul. 31 2013






1 comments In this Bonus Footage from Grae Drake's interview with Miles Teller and Shailene Woodley, the stars of The Spectacular Now, they confess their old IM names and your life will never be the same.

Source: http://www.rottentomatoes.com/m/1928004/news/1928004/

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Meet the toughest iPhone 5 cases money can buy

1. itsdeepak4u2000 posted on 1 hour ago 1

Some looks lovely and some are very ugly.

2. Luisit0 posted on 54 min ago 0

The orange lifreproof fre case is pathetic and 99% unlikely to ever be seen used by an iPhone owner....

3. scriptwriter posted on 52 min ago 0

"As many would agree, the iPhone 5 is a beautiful, well-crafted smartphone."

I do not agree with this.

4. chaoticrazor posted on 16 min ago 0

So why are you commenting..even looking at an article about iphone cases seeing as you just bore with your childish hate

Reported

Source: http://feedproxy.google.com/~r/phonearena/ySoL/~3/CphMYFpf02c/Meet-the-toughest-iPhone-5-cases-money-can-buy_id45904

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